Exemestane FAQ

What is the primary mechanism of action of Exemestane?

Exemestane permanently inactivates the aromatase enzyme through irreversible binding, which is why it is known as a "suicide inhibitor."

How does Exemestane differ from Anastrozole?

Exemestane is a steroidal, irreversible inhibitor, while Anastrozole is non-steroidal and reversibly binds. Exemestane's effects last until the body produces new enzyme.

What is the typical half-life and dosing for Exemestane?

Exemestane has a half-life of about 24 hours, making a once-daily dosing schedule of 12.5 mg to 25 mg standard for most users.

Can Exemestane cause low estrogen symptoms?

Yes, like all aromatase inhibitors, excessive dosing can crash estrogen levels, leading to joint pain, low mood, and fatigue.

Does Exemestane have any androgenic properties?

Due to its steroidal structure, it can have mild androgenic effects, though these are not typically significant at clinical doses.

Is Exemestane considered liver-toxic?

Exemestane is not noted for significant liver toxicity and is generally considered to have a favorable hepatotoxic profile compared to many other oral compounds.

How does Exemestane affect cholesterol levels?

While it can have some negative impact on lipid profiles, it is often considered to be less detrimental to cholesterol than non-steroidal aromatase inhibitors.

Can Exemestane be used during Post-Cycle Therapy (PCT)?

Yes, it is commonly used in PCT to prevent estrogen rebound after stopping a cycle of aromatizing steroids, helping to maintain a favorable testosterone-to-estrogen ratio.

What is a common clinical dose of Exemestane?

The standard clinical dose for breast cancer treatment is 25 mg once daily. In a performance context, doses are often adjusted based on individual response and needs.

Why is blood work important when using Exemestane?

Blood work is crucial to monitor estradiol (E2) levels directly, ensuring they remain in an optimal range to avoid the negative health impacts of both high and low estrogen.