Description
CJC-1295 DAC (Drug Affinity Complex) is a synthetic, long-acting growth hormone-releasing hormone (GHRH) analog. It is engineered to significantly extend the half-life of endogenous growth hormone (GH) release by binding to serum albumin in the bloodstream. This results in a sustained elevation of GH and insulin-like growth factor 1 (IGF-1) levels for several days from a single injection, making it a cornerstone of peptide protocols for recovery, body composition, and anti-aging.
Mechanism of Action
The mechanism of action for CJC-1295 DAC centers on its modification with a Drug Affinity Complex (DAC). This moiety allows the peptide to bind reversibly to albumin in the blood, dramatically slowing its clearance. As a GHRH analog, it continuously stimulates the pituitary gland to secrete pulses of growth hormone in a more natural, pulsatile manner, but against a backdrop of consistently elevated baseline GH levels. Unlike secretagogues (GHRP-6, GHRP-2), CJC-1295 DAC provides a sustained releasing signal rather than an acute stimulatory pulse.
Clinical Application and Dosage
CJC-1295 DAC has been investigated in clinical trials for growth hormone deficiency and its associated conditions. In performance and wellness contexts, it is used to promote increased lean muscle mass, enhanced fat loss, improved sleep quality, skin thickening, and accelerated recovery from training through its sustained elevation of GH/IGF-1.
Dosage of CJC-1295 DAC is typically low due to its high potency and long duration. Common research protocols involve subcutaneous injections of 1 mg to 2 mg, administered twice per week (e.g., Monday and Thursday). Some users employ lower, more frequent doses. The 2 mg vial of CJC-1295 DAC often constitutes a single dose or is split into two 1 mg doses, depending on the protocol. It must be reconstituted with bacteriostatic water and stored refrigerated.
Treatment Protocol and Monitoring
Cycles with CJC-1295 DAC are often longer, ranging from 8 to 12 weeks or more, to capitalize on the cumulative effects of elevated GH/IGF-1. Due to its long action, less frequent injections are required compared to other peptides. Monitoring should include attention to body composition changes, recovery metrics, and signs of common side effects. For long-term use, monitoring of fasting blood glucose and IGF-1 levels via blood work is advisable.
Pharmacological Profile
The defining pharmacological feature of CJC-1295 DAC is its extended half-life of approximately 6-8 days, courtesy of its albumin-binding DAC moiety. This allows for sustained GH release and stable elevated IGF-1 levels with a very infrequent dosing schedule. It is administered via subcutaneous injection. Once reconstituted, it requires refrigeration to maintain stability.
Common Side Effects
The side effect profile of CJC-1295 DAC is related to the sustained elevation of GH/IGF-1. The most common include:
- Injection Site Reactions: Redness, itching, or nodules at the injection site are relatively common.
- Headache: Can occur, especially at the beginning of a cycle or with higher doses.
- Fluid Retention and Edema: Mild to moderate water retention is frequent, potentially leading to carpal tunnel syndrome-like symptoms (numbness, tingling in hands).
- Joint Aches and Pain: Associated with increased connective tissue growth and fluid retention.
- Increased Hunger: A common effect of elevated GH, though usually less intense than with GHRP-6.
- Hyperglycemia: GH has anti-insulin effects, which can lead to elevated blood sugar levels with prolonged use.
Potential long-term risks mirror those of exogenous GH abuse, including insulin resistance, acromegaly-like symptoms (with extreme misuse), and organ growth. Its long-term safety profile is not fully established.
You can buy CJC-1295 DAC made by Apoxar in bulk in Canada via our website. Navigate to the “Purchase” tab and fill the contact form with details of your wholesale order. Please note: we do not sell single packs or ship directly to consumers, Apoxar is a wholesale fitness medication manufacturer and we work exclusively with our approved distributors.

