Description

Liothyronine Sodium is the synthetic sodium salt of the active thyroid hormone triiodothyronine (T3). It is a potent metabolic accelerator that directly increases the body’s basal metabolic rate (BMR), leading to enhanced caloric expenditure and fat loss. Liothyronine Sodium is used clinically for thyroid hormone replacement and, in a performance context, as a powerful but potentially catabolic cutting agent.

Mechanism of Action

The mechanism of action for Liothyronine Sodium is direct and systemic. Unlike its precursor thyroxine (T4), Liothyronine Sodium is the bioactive form of thyroid hormone that does not require conversion in peripheral tissues. It binds to thyroid hormone receptors in the nuclei of cells throughout the body, particularly in the liver, muscle, and fat tissue. This binding increases gene transcription for enzymes involved in cellular respiration and metabolism, leading to a significant increase in oxygen consumption, ATP turnover, and the breakdown of carbohydrates, fats, and proteins for energy. This drastically elevates the metabolic rate.

Clinical Application and Dosage

The primary clinical application of Liothyronine Sodium is the treatment of hypothyroidism, including myxedema coma, and in suppression tests for thyroid cancer. In performance and physique enhancement, Liothyronine Sodium is employed during cutting phases to accelerate fat loss beyond what diet and exercise alone can achieve, often stacked with other fat-loss agents.

Dosage of Liothyronine Sodium must be carefully titrated due to its potency and narrow therapeutic window. For fat loss, protocols typically start at a very low dose of 12.5 mcg to 25 mcg daily, split into two or three doses to mimic the body’s natural T3 secretion pattern. The dose may be gradually increased, but exceeding 75-100 mcg daily for extended periods is dangerous. The 25 mcg tablet strength of this Liothyronine Sodium formulation allows for precise dosing. Treatment should not be abrupt; a gradual taper off is required to allow the thyroid gland to resume natural function.

Treatment Protocol and Monitoring

Cycles with Liothyronine Sodium for fat loss are typically kept short to moderate (4-8 weeks) to minimize the risk of suppressing the body’s own thyroid production and causing muscle catabolism. Its thermogenic effects can be felt within hours of the first dose. Meticulous monitoring is critical and includes tracking resting heart rate and body temperature as proxies for metabolic rate. Blood pressure should be monitored due to potential cardiovascular stimulation. For any use beyond a few weeks, blood tests to assess thyroid function (TSH, Free T3, Free T4) are strongly advised.

Pharmacological Profile

Liothyronine Sodium is rapidly and almost completely absorbed from the gastrointestinal tract. It has a short half-life of approximately 2-3 days, but its metabolic effects are pronounced and require multiple daily doses to avoid peaks and troughs. It is not significantly bound to plasma proteins, making it immediately available to tissues. Liothyronine Sodium bypasses the body’s natural regulatory feedback on the pituitary and thyroid glands, meaning exogenous use suppresses endogenous T4 and T3 production.

Common Side Effects

The side effects of Liothyronine Sodium are primarily symptoms of hyperthyroidism (thyrotoxicosis) and are dose-dependent. The most common include:

• Increased Heart Rate and Palpitations: A direct result of heightened metabolic and cardiovascular activity.
• Excessive Sweating and Heat Intolerance.
• Anxiety, Nervousness, and Tremors.
• Insomnia.
• Increased Appetite: Paradoxically, as metabolism increases.
• Muscle Catabolism: At higher doses or in a severe caloric deficit, Liothyronine Sodium can break down muscle tissue for energy, counteracting anabolic goals.
• Permanent Thyroid Suppression: With prolonged, high-dose use, the thyroid gland may not fully recover its function.

Liothyronine Sodium is contraindicated in individuals with uncontrolled cardiovascular disease, adrenal insufficiency, or untreated hyperthyroidism. Its improper use carries significant risks of cardiac arrhythmia, bone mineral density loss, and severe metabolic disruption.

You can buy Liothyronine Sodium made by Apoxar in bulk in Canada via our website. Navigate to the “Purchase” tab and fill the contact form with details of your wholesale order. Please note: we do not sell single packs or ship directly to consumers, Apoxar is a wholesale fitness medication manufacturer and we work exclusively with our approved distributors.