Description
Methandrostenolone is a classic and potent oral anabolic steroid, renowned for its powerful ability to promote rapid gains in muscle mass and strength. As one of the first widely used performance-enhancing drugs, Methandrostenolone is characterized by its strong anabolic effects coupled with significant estrogenic activity, leading to substantial water and glycogen retention that contributes to dramatic increases in size and weight in a short period.
Mechanism of Action
The mechanism of action for Methandrostenolone is multifaceted. It binds strongly to androgen receptors, directly stimulating protein synthesis and nitrogen retention. A defining characteristic of Methandrostenolone is its high rate of aromatization; it readily converts to estrogen via the aromatase enzyme. This estrogenic activity promotes intracellular water retention, glycogen storage, and increases in IGF-1 production, all of which contribute to its potent mass-building effects and the characteristic “puffy” look. However, this same mechanism is responsible for its common estrogenic side effects.
Clinical Application and Dosage
Methandrostenolone had limited historical clinical use but has been largely discontinued due to its side effect profile. In performance and physique enhancement, Methandrostenolone is a foundational bulking agent, often used at the beginning of a cycle to provide a rapid “kickstart” of size and strength while longer-acting injectables take effect.
Dosage of Methandrostenolone is potent. For men, common daily dosages range from 25 mg to 50 mg, often split into two doses (e.g., morning and evening) to maintain stable blood levels. The 20 mg tablet strength of this Methandrostenolone formulation allows for flexible dosing within this range. Cycles are strictly limited to 4-6 weeks due to its pronounced hepatotoxicity and side effects. For women, the risk of virilization is very high, and its use is generally not recommended.
Treatment Protocol and Monitoring
A cycle with oral Methandrostenolone is kept short, typically 4-6 weeks. Dramatic increases in weight (largely from water) and strength can be seen within the first 7-10 days. Rigorous health monitoring is mandatory. This must include blood tests before, during, and after the cycle to check liver enzymes (AST/ALT), which will be significantly elevated, and lipid profiles, as Methandrostenolone severely worsens cholesterol ratios. Blood pressure must also be closely monitored due to water retention.
Pharmacological Profile
Methandrostenolone is a 17-alpha-alkylated anabolic steroid, which allows it to be orally bioavailable but confers significant hepatotoxicity. It has a relatively short half-life of approximately 3-6 hours, necessitating multiple daily doses. It is a strong aromatizer and is metabolized in the liver. Its effects are rapid but not sustainable off-cycle due to the loss of water weight.
Common Side Effects
The use of Methandrostenolone is associated with a significant and well-documented range of side effects. The most common include:
- Severe Hepatotoxicity: Causes pronounced stress on the liver, with sharp elevations in liver enzymes.
- Pronounced Estrogenic Effects: Significant water retention (bloat), high blood pressure, and a high risk of gynecomastia.
- Catastrophic Lipid Impact: Dramatically lowers HDL (“good”) cholesterol and raises LDL, posing a serious cardiovascular risk.
- Suppression of Natural Testosterone: Profound and rapid shutdown of the HPTA.
- Androgenic Effects: Acne, oily skin, and potential acceleration of male pattern baldness.
More serious risks with abuse include hepatotoxicity leading to liver damage, and significant cardiovascular strain. Methandrostenolone is contraindicated for individuals with pre-existing liver, cardiovascular, kidney, or prostate conditions.
You can buy Methandrostenolone made by Apoxar in bulk in Canada via our website. Navigate to the “Purchase” tab and fill the contact form with details of your wholesale order. Please note: we do not sell single packs or ship directly to consumers, Apoxar is a wholesale fitness medication manufacturer and we work exclusively with our approved distributors.