Description

Gonadotropin, specifically Human Chorionic Gonadotropin (hCG), is a polypeptide hormone that mimics the action of luteinizing hormone (LH) in the body. It is a critical ancillary medication in endocrinology and performance enhancement, primarily used to stimulate testosterone production and prevent testicular atrophy during or after a cycle of suppressive compounds.

Mechanism of Action

The mechanism of action for Gonadotropin is direct stimulation of the Leydig cells in the testes. By binding to the luteinizing hormone/choriogonadotropin receptor (LHCGR), Gonadotropin signals the testes to produce and secrete testosterone, even when the body’s own pituitary signal (LH) is suppressed. This action helps maintain testicular size, function, and hormonal infrastructure, which can significantly improve recovery of the hypothalamic-pituitary-testicular axis (HPTA) after the cessation of anabolic steroids.

Clinical Application and Dosage

The clinical application of Gonadotropin includes the treatment of hypogonadotropic hypogonadism and induction of ovulation in fertility treatments. In a performance context, Gonadotropin is used either on-cycle to prevent testicular shutdown or as a crucial component of post-cycle therapy (PCT) to restart natural testosterone production.

Gonadotropin dosage is highly dependent on its application. For on-cycle maintenance during a steroid cycle, common protocols involve 250 IU to 500 IU injected subcutaneously or intramuscularly two to three times per week. For post-cycle therapy, a short blast of 1000-2000 IU every other day for 10-16 days may be used, followed by SERM therapy. The 5000 IU vial of Gonadotropin provides multiple doses and must be reconstituted with bacteriostatic water and refrigerated after mixing.

Treatment Protocol and Monitoring

Protocols using Gonadotropin are typically integrated into a larger hormonal management plan. When used on-cycle, it is administered from the start or midpoint of the cycle until the beginning of PCT. As a PCT kickstart, it is used for a short, defined period. Monitoring the effectiveness of Gonadotropin therapy can involve observing for the return of testicular volume and, ideally, blood work to assess testosterone levels. Overuse can lead to receptor desensitization.

Pharmacological Profile

Gonadotropin is a glycoprotein administered via subcutaneous or intramuscular injection. It has a half-life of approximately 24-36 hours, which is significantly longer than natural LH, making intermittent dosing effective. Once reconstituted, it must be stored refrigerated and used within a specified timeframe (often 30-60 days) due to its peptide nature. Its effects are dose-dependent and receptor-mediated.

Common Side Effects

While generally well-tolerated, Gonadotropin use is associated with specific side effects, particularly at higher doses. The most common include:

• Elevated Estrogen: Gonadotropin stimulates intratesticular aromatase, which can lead to increased conversion of the newly produced testosterone to estradiol, potentially causing gynecomastia, water retention, and mood swings.
• Androgenic Effects: As it increases endogenous testosterone, side effects like acne or aggravated hair loss in predisposed individuals can occur.
• Receptor Desensitization: High doses or prolonged use can downregulate Leydig cell LHCG receptors, potentially impairing long-term recovery.
• Ovarian Hyperstimulation Syndrome (OHSS): A serious risk in female fertility use, but not applicable to male performance use.
• Headaches and Fatigue: Some users report these symptoms.

Gonadotropin is contraindicated in individuals with androgen-dependent cancers (e.g., prostate cancer). Its use requires careful estrogen management, often with an aromatase inhibitor.

You can buy Gonadotropin (hCG) made by Apoxar in bulk in Canada via our website. Navigate to the “Purchase” tab and fill the contact form with details of your wholesale order. Please note: we do not sell single packs or ship directly to consumers, Apoxar is a wholesale fitness medication manufacturer and we work exclusively with our approved distributors.