Drostanolone Enanthate (Masteron) 200 mg/mL

Substance: Drostanolone Enanthate
Form: Injectable solution, oil-based
Common names: Masteron, Mast E
Dosage: 200 mg/mL
Packaging: 10 mL vial
Purity: >99%

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SKU: MASTERON2 Category:

Description

Drostanolone Enanthate is a potent, long-acting injectable anabolic-androgenic steroid derived from dihydrotestosterone (DHT), specifically engineered for promoting extreme muscle hardness, density, and a sharply defined physique. Its development provided a critical tool for competitive bodybuilders and athletes seeking peak physical conditioning without estrogenic interference, making it a cornerstone of contest preparation protocols.

Mechanism of Action

The substance works through a dual mechanism to achieve its distinctive effects. Primarily, it binds strongly to androgen receptors in muscle tissue, directly stimulating pathways for protein synthesis and lean tissue accretion. Secondly, and crucially, it functions as a competitive inhibitor of the aromatase enzyme. This anti-estrogenic activity prevents the conversion of androgens into estrogens, thereby eliminating water retention, gynecomastia, and other estrogen-mediated side effects, which is fundamental to achieving a dry, hard muscular appearance.

Clinical Application and Dosage

The clinical application of Drostanolone Enanthate is highly specialized within performance contexts due to its potent androgenic nature and lack of approved therapeutic uses for muscle wasting. It is indicated almost exclusively for use during cutting or pre-contest phases to enhance muscular definition and vascularity.

A critical component of its effective use is the prerequisite of low body fat levels, typically below 12%, to fully reveal its hardening effects. The dosage is individualized based on experience level and cycle goals, typically ranging from 200 mg to 600 mg per week, administered via intramuscular injection due to its long enanthate ester. It is almost universally combined with a testosterone base to maintain physiological function.

Treatment Protocol and Monitoring

A standard cycle incorporating Drostanolone Enanthate typically lasts 8 to 12 weeks, with noticeable effects on muscle hardness and density accruing over several weeks. Throughout use, individuals must undergo regular monitoring, which includes baseline and follow-up blood tests to assess lipid profiles and liver enzymes, as negative impacts are common. Blood pressure should also be routinely checked due to potential androgenic cardiovascular effects.

Pharmacological Profile

The pharmacological profile of Drostanolone Enanthate is characterized by its administration as an oil-based injectable solution and the presence of the enanthate ester, which provides a slow release of the active hormone and a half-life of approximately 10-14 days. It exhibits no aromatase activity and is metabolized in the liver. Its metabolites are excreted primarily in urine.

Common Side Effects

While highly effective for its purpose, use of Drostanolone Enanthate is associated with a well-documented range of potential side effects, which are primarily androgenic and metabolic. The most common include:

  • Androgenic Effects: Acne, accelerated male pattern hair loss, and increased body hair growth in genetically predisposed individuals.
  • Lipid Profile Impact: A pronounced negative effect on cholesterol, significantly suppressing HDL (good cholesterol) and potentially elevating LDL.
  • Testosterone Suppression: Profound inhibition of endogenous testosterone production, necessitating a Testosterone Replacement base and post-cycle therapy.
  • Hepatotoxicity: Mild strain on the liver, though less severe than oral 17-α-alkylated compounds.

More serious, though less common, concerns include potential exacerbation of benign prostatic hyperplasia (BPH) and significant cardiovascular strain from altered lipid ratios. Its use is absolutely contraindicated in individuals with pre-existing liver, cardiovascular, or prostate conditions.

You can buy Drostanolone Enanthate made by Apoxar in bulk in Canada via our website. Navigate to the “Purchase” tab and fill the contact form with details of your wholesale order. Please note: we do not sell single packs or ship directly to consumers, Apoxar is a wholesale fitness medication manufacturer and we work exclusively with our approved distributors.

FAQ

What is Drostanolone Enanthate and what is its primary medical use?

Drostanolone Enanthate is a long-acting ester of the synthetic anabolic-androgenic steroid (AAS) drostanolone. Its primary, and now largely historical, medical use was in the palliative treatment of advanced, inoperable breast cancer in postmenopausal women, where it functioned as an anti-estrogen.

What is the main mechanism of action for Drostanolone Enanthate?

Drostanolone Enanthate acts as a competitive antagonist at the estrogen receptor. It binds to receptors in estrogen-sensitive tissues, such as breast tissue, and blocks the proliferative effects of natural estrogens, thereby slowing the growth of hormone-responsive cancer cells.

For which performance or physique-related goals is Drostanolone Enanthate commonly utilized?

In performance contexts, Drostanolone Enanthate is primarily used during "cutting" or pre-contest phases. It is favored for its ability to promote a hard, dense, and lean muscular appearance with minimal water retention, and it may enhance muscular definition without significant mass gain.

What is a typical administration protocol for Drostanolone Enanthate?

A typical protocol involves intramuscular injections, often in a range of 200 to 400 mg per week, due to its enanthate ester providing a release duration of approximately one week. Dosages are highly variable and depend on individual response, cycle structure, and experience level.

What are the most frequently reported side effects of Drostanolone Enanthate?

Common androgenic side effects include oily skin, acne, and accelerated hair loss in individuals predisposed to male pattern baldness. It can also suppress natural testosterone production and may negatively impact cardiovascular health markers, such as HDL ("good") cholesterol.

Why is post-cycle therapy (PCT) often considered after using Drostanolone Enanthate?

Post-cycle therapy is crucial because Drostanolone Enanthate, like most anabolic steroids, suppresses the hypothalamic-pituitary-gonadal (HPG) axis. PCT aims to stimulate the natural restoration of endogenous testosterone production to prevent hypogonadal symptoms and maintain gains.

How does Drostanolone Enanthate differ from other steroids like testosterone enanthate?

While both share the same enanthate ester, they are fundamentally different compounds. Testosterone is a potent estrogenic mass-building steroid, whereas Drostanolone is a dry, non-estrogenic compound known for enhancing muscle quality and hardness without significant water or fat retention.

Can Drostanolone Enanthate be effectively combined with other compounds?

Yes, it is frequently stacked with other agents. Common combinations include a testosterone base for physiological support, along with other non-estrogenic compounds like Trenbolone or oral Stanozolol during cutting phases to maximize a lean, vascular physique.

What are the critical monitoring considerations during its use?

Regular monitoring of cardiovascular lipid profiles (especially HDL and LDL cholesterol), liver enzymes (although it is not 17-alpha-alkylated), and hematocrit levels is advised. Blood pressure should also be checked regularly due to potential negative impacts on vascular health.

What is its legal status and how does that impact use?

Drostanolone Enanthate is a Schedule III controlled substance in the United States and is similarly classified in many other countries. It is illegal to possess or distribute without a prescription, which severely limits its legitimate availability to performance-oriented use outside of regulated medical settings.

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