Description
Yohimbine is a potent alkaloid derived from the bark of the Pausinystalia yohimbe tree. It functions as a selective alpha-2 adrenergic receptor antagonist, a mechanism that promotes lipolysis (fat breakdown) and increases norepinephrine levels. Yohimbine is widely used as a supplement for fat loss, particularly targeting stubborn adipose tissue, and is also recognized for its application in treating sexual dysfunction.
Mechanism of Action
The mechanism of action for Yohimbine centers on its blockade of alpha-2 adrenergic receptors. These receptors, when activated, inhibit the release of norepinephrine and suppress fat breakdown in adipose tissue. By antagonizing these receptors, Yohimbine increases sympathetic nervous system output, leading to elevated levels of norepinephrine. This enhances lipolysis, especially in fat areas with a high density of alpha-2 receptors (like the lower abdomen and hips). Additionally, Yohimbine increases blood flow and may impact sexual function by acting on receptors in the brain and genitalia.
Clinical Application and Dosage
Yohimbine has a clinical history as a prescription medication for erectile dysfunction, though its use has been largely superseded by more effective drugs. In performance and supplementation contexts, Yohimbine is primarily employed as a cutting agent to aid in stubborn fat loss and to increase energy and focus during fasted training.
The dosage of Yohimbine is critical due to its narrow effective window and potential for side effects. For fat loss, common protocols recommend 0.1 mg to 0.2 mg per kilogram of body weight, taken in divided doses. A typical starting dose is 2.5 mg to 5 mg, taken on an empty stomach, often 30-60 minutes before fasted cardio. The 5 mg tablet strength of this Yohimbine formulation allows for precise dosing. It is not recommended to exceed 15-20 mg per day.
Treatment Protocol and Monitoring
Yohimbine is used intermittently, typically during a cutting phase for 4-8 weeks. It is most effective when combined with a caloric deficit and fasted aerobic exercise. Users should closely monitor their tolerance, starting with the lowest effective dose. Due to its impact on heart rate and blood pressure, monitoring resting heart rate and subjective feelings of anxiety or jitteriness is advised. Cycling off Yohimbine is recommended to prevent receptor adaptation.
Pharmacological Profile
Yohimbine is an indole alkaloid with good oral bioavailability. It has a relatively short half-life of approximately 0.5 to 2.5 hours, which necessitates timing its intake around activity. It is metabolized in the liver and its effects are dose-dependent. The effects of Yohimbine are pronounced on an empty stomach, as insulin can blunt its lipolytic action.
Common Side Effects
Yohimbine is a potent compound with a significant side effect profile, especially at higher doses. The most common include:
- Anxiety and Jitteriness: Due to increased norepinephrine.
- Increased Heart Rate and Blood Pressure: A direct result of its adrenergic effects.
- Nausea and Gastrointestinal Distress: Particularly on an empty stomach.
- Headaches and Dizziness.
- Insomnia: If taken too late in the day.
- Skin Flushing and Sweating.
- Panic Attacks: In sensitive individuals or with overdose.
Due to its potent cardiovascular and neurological effects, Yohimbine is contraindicated for individuals with anxiety disorders, heart conditions, hypertension, kidney disease, or who are taking mood-altering medications (MAOIs, SSRIs, etc.). It is not recommended for beginners or those sensitive to stimulants.
You can buy Yohimbine made by Apoxar in bulk in Canada via our website. Navigate to the “Purchase” tab and fill the contact form with details of your wholesale order. Please note: we do not sell single packs or ship directly to consumers, Apoxar is a wholesale fitness medication manufacturer and we work exclusively with our approved distributors.